Rune Factory 5 requires players to not only farm resources and craft items and tools, but also to create their own medicines. Medicines can heal health points, restore stats, cure poison and sickness, and can even boost friendship points when given as a gift. Each item can be created with a few ingredients, just follow the recipes below.
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Chemistry Recipe List for Rune Factory 5
| Item | Ingredients | Effect | Skill Level |
| Recovery Potion | Medicinal Herb + Green Grass | HP recovery +150 | 3 |
| Sweet Powder | Apple | Water resistance -30% | 5 |
| Sour Crop | Orange | Earth resistance -30% | 7 |
| Healing Potion | Medicinal Herb + Red Grass | HP recovery +800 | 7 |
| Mixed Herbs | Green Grass + Toy Herb | Wind resistance -30% | 8 |
| Heavy Spice | Purple Grass | Fire resistance -30% | 10 |
| Roundoff | Black Grass + Black Grass | HP recovery +800 | 13 |
| Healing Potion | Pom-Pom Grass | HP recovery +800 | 14 |
| Recovery Potion | Blue Grass | HP recovery +150 | 15 |
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| Para-Gone | Indigo Grass + Indigo Grass | HP recovery +50, Cures paralysis | 18 |
| Cold Medicine | Orange Grass + Toy Herb | HP recovery +1000, Cures sickness | 22 |
| Antidote Potion | Antidote Herb + Yellow Grass | HP recovery +1500, Cures poison | 25 |
| No Rot a | Withered Grass + Toy Herb | Prevents plants from wilting | 26 |
| Mystery Potion | Medicinal Herb + White Grass | HP recovery +3000 | 33 |
| Magical Potion | Medicinal Herb + Elli Leaves | HP recovery +50% | 45 |
| Formuade | Heavy Spicy + Lamp Grass + Iron Leaf + Liquid Type + Powders or Spores | Max. HP -50%, STR +70%, VIT +70%, CRIT +20%, All ailment resist +25% | 46 |
| Invinciroid | Formuade + Autumn Grass + Hot-Hot Fruit +Noel Grass + Emery Flower | Cures all ailments, immune to them for 12hrs game time, HP recovery +100%, RP recovery +100%, STR +50%/10%, VIT +50%/10%, INT +50%/10% | 76 |
| The Protein | Red Crystal + Red Crystal + Spinach + Liquid Type + Powders or Spores | Permanently raises STR by +1 | 80 |
| Vital Gummi | Blue Crystal + Blue Crystal + Bok Choy + Liquid Type + Powders or Spores | Permanently raises VIT by +1 | 83 |
| Love Potion | Grape Liqueur + Pink Melon + Strawberry + Honey + Hot-Hot Fruit +Emery Flower | RP recovery +50%, Cures all status ailments, Knockback resist +10%, Crit resist +50%, All status ailment +25%. Raises a high amount of friendship points when given as a gift to some. | 87 |
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Complete Chemistry Recipes List in Rune Factory 5